(3S) -Tanzisertib hydrochloride
Product Specifications
CAS Number
2517855-91-1
Target
P38 MAPK, ERK, JNK, EGFR, TNF
Related Pathways
MAPK, Apoptosis, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
(3S) -Tanzisertib (hydrochloride) ((3S) -CC-930 (hydrochloride) ) is an orally active JNK inhibitor, exhibiting IC50 values of 61 nM for JNK1, 7 nM for JNK2, and 6 nM for JNK3. It selectively inhibits ERK1, p38α, and EGFR, with IC50 values of 0.48 μM, 3.4 μM, and 0.38 μM, respectively. In an acute rat PK-PD model, (3S) -Tanzisertib (hydrochloride) suppresses LPS-induced TNFα production and is utilized in research on idiopathic pulmonary fibrosis (IPF) .
Smiles
N(C=1N(C=2C(N1)=CN=C(NC3CCC(O)CC3)N2)[C@H]4CCOC4)C5=C(F)C=C(F)C=C5F.Cl
Molecular Formula
C21H24ClF3N6O2
Molecular Weight
484.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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