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(3S) -Tanzisertib hydrochloride

Product Specifications

CAS Number

2517855-91-1

Target

P38 MAPK|||ERK|||JNK|||EGFR|||TNF

Related Pathways

MAPK|||Apoptosis|||Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

Bioactivity

(3S) -Tanzisertib (hydrochloride) ((3S) -CC-930 (hydrochloride) ) is an orally active JNK inhibitor, exhibiting IC50 values of 61 nM for JNK1, 7 nM for JNK2, and 6 nM for JNK3. It selectively inhibits ERK1, p38?, and EGFR, with IC50 values of 0.48 ?M, 3.4 ?M, and 0.38 ?M, respectively. In an acute rat PK-PD model, (3S) -Tanzisertib (hydrochloride) suppresses LPS-induced TNF? production and is utilized in research on idiopathic pulmonary fibrosis (IPF) .

Smiles

N(C=1N(C=2C(N1)=CN=C(NC3CCC(O)CC3)N2)[C@H]4CCOC4)C5=C(F)C=C(F)C=C5F.Cl

Molecular Formula

C21H24ClF3N6O2

Molecular Weight

484.9

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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