JAK3-IN-17

Product Specifications

Target

JAK

Related Pathways

Stem Cells|||JAK/STAT signaling|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis

Bioactivity

JAK3-IN-17 is an orally active JAK3 inhibitor with an IC50 of 14.56 nM. It demonstrates anti-inflammatory activity by inhibiting the production of IL-2 and IL-6 in a DNCB-induced mouse model of atopic dermatitis.

Smiles

FC1=NC=CC=C1C(C=C2)=CN3C2=NC=C3C4=CC(NC(C=C)=O)=CC=C4

Molecular Formula

C21H15FN4O

Molecular Weight

358.37

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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