IRAK1/4/pan-FLT3 Kinase-IN-2
Product Specifications
CAS Number
2760329-44-8
Target
IRAK
Related Pathways
Immunology/Inflammation, NF-κB
Bioactivity
IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.
Smiles
FC1=C(C=2N3C(C=C(OC(C)C)C=C3)=NC2)N=C(N[C@@H]4[C@@H](F)CCNC4)C(F)=C1
Molecular Formula
C20H22F3N5O
Molecular Weight
405.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940034-100 1x 100 µL
Cytokeratin 8/18 (C-51), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470409-100 1x 100 µL
UPK3A (Uroplakin 3A) (Rabbit PAb), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400879-100 1x 100 µL
P57 / KIP2 (KP10), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details