EG31
Product Specifications
CAS Number
360760-58-3
Target
EGFR
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.
Smiles
O=C1OC(=NC2=CC=C(Br)C=C12)C=3C=C(C=C(C3)N4C(=O)C=5C=CC=CC5C4=O)C6=NC7=CC=C(Br)C=C7C(=O)O6
Molecular Formula
C30H13Br2N3O6
Molecular Weight
671.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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