SMU-14a
Product Specifications
Target
TLR, IκB/IKK, NF-κB, p38 MAPK, ERK, TNF
Related Pathways
NF-κB, Immunology/Inflammation, MAPK, Apoptosis
Bioactivity
SMU-14a is a TLR3 inhibitor with an IC50 of 0.18 μM. It suppresses IL-6 secretion in mouse peritoneal macrophages and downregulates TNF-α in human peripheral blood mononuclear cells. The compound exerts anti-inflammatory effects by reducing the phosphorylation of p65, ERK, and TBK1 via the NF-κB, MAPK, and IRF3 signaling pathways, and by lowering serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) . SMU-14a is applicable in acute hepatitis research.
Molecular Formula
C24H20N4O
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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