DEG-35
Product Specifications
CAS Number
2734910-37-1
Target
Casein Kinase, IKZF, Molecular Glues
Related Pathways
PROTAC, Metabolism, Stem Cells, Immunology/Inflammation
Bioactivity
DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML) .
Smiles
O=C(NC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=C5C=C(OC)C=CC5=C4
Molecular Formula
C25H21N3O5
Molecular Weight
443.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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