NF-?B/HIF-1?-IN-1

NF-?B/HIF-1?-IN-1 (compound 9c) effectively inhibits the NF-?B activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-?B/HIF-1?-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-?B and HIF-1?, and induces Nrf2.