NF-?B/HIF-1?-IN-1
Product Specifications
Target
HIF/HIF Prolyl-Hydroxylase|||NF-?B|||Nrf2
Related Pathways
Immunology/Inflammation|||Chromatin/Epigenetic|||NF-?B|||Metabolism
Bioactivity
NF-?B/HIF-1?-IN-1 (compound 9c) effectively inhibits the NF-?B activation pathway and demonstrates selective antifibrotic activity. This compound exhibits no significant cytotoxicity in NCI tumor cell lines. In rat models, NF-?B/HIF-1?-IN-1 successfully ameliorates liver fibrosis, suppresses the expression levels of NF-?B and HIF-1?, and induces Nrf2.
Molecular Formula
C24H27N7O4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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