Mrgx2 antagonist-3
Product Specifications
CAS Number
2641397-91-1
Target
MRGPR
Related Pathways
GPCR/G Protein
Bioactivity
Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.
Smiles
O=C1C(=C(N=C2NC3=CC(F)=C(F)C=C3N12)C(C)C)CC
Molecular Formula
C15H15F2N3O
Molecular Weight
291.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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