KIM-161
Product Specifications
CAS Number
2559686-28-9
Target
PI3K, Reactive Oxygen Species, Akt, Apoptosis, mTOR
Related Pathways
NF-κB, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis, Metabolism
Bioactivity
KIM-161 is a PIK3CA inhibitor. It demonstrates significant antiproliferative activity, with IC50 values of 1.428 and 1.562 μM against PI3KCA-mutant breast cancer cell lines MCF7 and T47D, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway, leading to ROS production. It is applicable for research on breast cancer and its PI3KCA-mutant subtypes.
Smiles
O=C\1N(C(C)=N/C1=C\C2=CC=C(OC)C=C2)C3=CC=C(CC(NCC4=CC=CC=C4)=O)C=C3
Molecular Formula
C27H25N3O3
Molecular Weight
439.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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