What is the catalog number for ALK-IN-31?

The catalog number for ALK-IN-31 is T207183.

What sizes are available for ALK-IN-31?

ALK-IN-31 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does ALK-IN-31 come in?

ALK-IN-31 is available in 2 different pack sizes.

Is ALK-IN-31 in stock?

ALK-IN-31 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ALK-IN-31?

ALK-IN-31 is manufactured by Molfinity.

What is the estimated delivery time for ALK-IN-31?

Estimated delivery time for ALK-IN-31 is approximately 10 business day(s), depending on your location.

ALK-IN-31

Product Specifications

CAS Number

3043840-25-8

Target

ALK, Apoptosis, Akt, mTOR

Related Pathways

Angiogenesis, Apoptosis, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

Bioactivity

ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor with an IC50 of 1135 nM. It demonstrates excellent antiproliferative activity against lung cancer cells H2228, with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation at the G0/G1 phase by affecting mitochondrial function. It exhibits antitumor effects by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. This compound is applicable for research into non-small cell lung cancer (NSCLC) .