ALK-IN-31
Product Specifications
CAS Number
3043840-25-8
Target
ALK|||Apoptosis|||Akt|||mTOR
Related Pathways
Angiogenesis|||Apoptosis|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling
Bioactivity
ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor with an IC50 of 1135 nM. It demonstrates excellent antiproliferative activity against lung cancer cells H2228, with an IC50 value of 1.35 ?M. ALK-IN-31 induces apoptosis and arrests cell proliferation at the G0/G1 phase by affecting mitochondrial function. It exhibits antitumor effects by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. This compound is applicable for research into non-small cell lung cancer (NSCLC) .
Smiles
O=C1C2=CC=C(C=C2CCC1)NC=3N=C(NC=4C=CC=CC4NC(=O)C5CCCCC5)C6=C(N3)CCSC6
Molecular Formula
C30H33N5O2S
Molecular Weight
527.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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