AKR1C3-IN-15
Product Specifications
CAS Number
3059671-44-9
Target
Reductase|||Apoptosis
Related Pathways
Metabolism|||Endocrinology/Hormones|||Apoptosis
Bioactivity
AKR1C3-IN-15 (compound 30) is an effective and selective AKR1C3 inhibitor with an IC50 value of 5 nM. It enhances Sorafenib-induced ROS production, promotes apoptosis, and restores sensitivity to Sorafenib in hepatocellular carcinoma (HCC) models, as demonstrated in both in vitro and in vivo studies.
Smiles
O=C(O)C1=CC=C(C=C1)CN(C(=O)C2=CC=3C=CC(F)=CC3OC2)C
Molecular Formula
C19H16FNO4
Molecular Weight
341.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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