H052
Product Specifications
CAS Number
2886748-00-9
Target
Calcium Channel, Antibacterial
Related Pathways
Membrane transporter/Ion channel, Metabolism, Microbiology/Virology
Bioactivity
H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla) . It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.
Smiles
O=C1NC=2C=C(C(=CC2NC1=O)S(=O)(=O)NC3=CC=C(C(Cl)=C3)C=4C=CC(F)=CC4)C
Molecular Formula
C21H15ClFN3O4S
Molecular Weight
459.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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