PROTAC MNK1 degrader-1
Product Specifications
Target
PERK, PROTACs, Apoptosis, MNK
Related Pathways
Apoptosis, PROTAC, MAPK
Bioactivity
ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.
Smiles
O=C(C1CCN(C(CCCCCC(NC2=C(CN(C3C(NC(CC3)=O)=O)C4=O)C4=CC=C2)=O)=O)CC1)NC(S5)=NC=C5C6=CC=CC=C6
Molecular Formula
C35H38N6O6S
Molecular Weight
670.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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