MS479
Product Specifications
Target
Epigenetic Reader Domain|||PROTACs
Related Pathways
Chromatin/Epigenetic|||PROTAC
Bioactivity
MS479 is a BRD4 PROTAC degrader that binds with high affinity to BRD4-BD2 and GLP (BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM) . It effectively reduces the protein levels of BRD4 short isoforms. By directly binding to its substrate GLP, MS479 recruits the E3 ligase SPOP as a bridging protein. Additionally, MS479 can be utilized to inhibit the proliferation of colorectal cancer cells.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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