HEMTAC WEE1 degrader-1
Product Specifications
CAS Number
3002417-64-0
Target
HSP|||Wee1
Related Pathways
Cytoskeletal Signaling|||Cell Cycle/Checkpoint|||Metabolism
Bioactivity
HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML) . HEMTACWEE1degrader-1 is utilized in AML research.
Smiles
O=C(NCC)C1=NN=C(C=2C=C(C(O)=CC2O)C(C)C)N1C3=CC=C(C=C3)CN4CCN(CC(=O)NCCCCN5CCN(C6=CC=C(C=C6)NC7=NC=C8C(=O)N(N(C=9N=C(C=CC9)C(O)(C)C)C8=N7)CC=C)CC5)CC4
Molecular Formula
C57H71N15O6
Molecular Weight
1062.27
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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