EGFR-IN-159
Product Specifications
CAS Number
2055746-08-0
Target
EGFR
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling
Bioactivity
EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 ?g/mL and 35.98 ?g/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.
Smiles
O=C1NC(=C(C(=O)NC=2C=CC=CC2OC)C(N1)C3=CC=C(O)C(OCC)=C3)C
Molecular Formula
C21H23N3O5
Molecular Weight
397.424
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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