TYD-68
Product Specifications
Target
JAK, STAT, PROTACs
Related Pathways
Chromatin/Epigenetic, Angiogenesis, Stem Cells, PROTAC, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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