What is the catalog number for LO-4-25?

The catalog number for LO-4-25 is T206941.

What sizes are available for LO-4-25?

LO-4-25 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does LO-4-25 come in?

LO-4-25 is available in 2 different pack sizes.

LO-4-25 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures LO-4-25?

LO-4-25 is manufactured by Molfinity.

What is the estimated delivery time for LO-4-25?

Estimated delivery time for LO-4-25 is approximately 10 business day(s), depending on your location.

LO-4-25

Product Specifications

Target

Androgen Receptor

Related Pathways

Endocrinology/Hormones

Bioactivity

LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.