TCL1
Product Specifications
CAS Number
875165-39-2
Target
Proteasome
Related Pathways
Proteases/Proteasome|||Ubiquitination
Bioactivity
TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 ?M. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
Smiles
O=C(O)CC1SC2=NN=C(N2N=C1C=3C=CC(Cl)=CC3)CC4=CC=C(Br)C=C4
Molecular Formula
C19H14BrClN4O2S
Molecular Weight
477.762
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
