AX-53802
Product Specifications
CAS Number
1008482-71-0
Target
Ferroptosis, Glutathione Peroxidase
Related Pathways
Apoptosis, Metabolism
Bioactivity
AX-53802 is a ferroptosis (ferroptosis) inducer targeting GPX4, with an IC50 of 0.34 μM. It forms a covalent bond with GPX4, initiating membrane translocation upon binding. In combination with FAK/Src inhibitors, AX-53802 enhances cell death. This compound is applicable in cancer research.
Smiles
O=C(C#C)N(C1=CC=C2OCOC2=C1)C(C(=O)NC3CCCC3)C=4C=CC=CC4F
Molecular Formula
C23H21FN2O4
Molecular Weight
408.422
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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