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Autotaxin-IN-7

Product Specifications

Target

PDE, TGF-beta/Smad

Related Pathways

Stem Cells, Metabolism

Bioactivity

Autotaxin-IN-7 (45) is a pyridine-2-carboxylic acid derivative exhibiting sub-nanomolar inhibition of ATX (IC50 = 0.086 nM) and features excellent cardiac safety (hERG > 30 μM) with minimal toxicity to fibroblasts. It inhibits the TGF-β/Smad signaling pathway, reducing α-smooth muscle actin (α-SMA) and extracellular matrix components (ECM) . Autotaxin-IN-7 (45) can be used in pulmonary fibrosis research.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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