VU0467319
Product Specifications
CAS Number
1432438-14-6
Target
AChR
Related Pathways
Neuroscience
Bioactivity
VU0467319 (Compound VU319) is a highly selective positive allosteric modulator of the M1 receptor, capable of crossing the blood-brain barrier and orally active, with an EC50 of 492 nM. It demonstrates selectivity in humans and rats (EC50 > 30 μM) compared to M2-5 receptors. This compound improves cognitive deficits associated with Alzheimer's disease (AD) through central M1 muscarinic receptor activation and does not induce cholinergic adverse effects, highlighting its potential in AD research.
Smiles
O=C1C2=CC=CN=C2CN1CC=3C(F)=CC(=CC3F)C4=CC=CC5=NN(C=C54)C
Molecular Formula
C22H16F2N4O
Molecular Weight
390.385
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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