LIB3S0280
Product Specifications
Target
Apoptosis, IκB/IKK, Akt
Related Pathways
NF-κB, Apoptosis, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Bioactivity
LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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