AR antagonist 11
Product Specifications
CAS Number
3005979-40-5
Target
Serine Protease, Androgen Receptor
Related Pathways
Endocrinology/Hormones, Proteases/Proteasome
Bioactivity
AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM) . Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM) . This compound is applicable in prostate cancer (PCa) research.
Smiles
ClC1=CC=C([C@H]2[C@@]3([C@](C=4C=5C(C=CC4N2)=NC=CC5)(OCC3)[H])[H])C=C1
Molecular Formula
C20H17ClN2O
Molecular Weight
336.815
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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