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PARP1-IN-37

Product Specifications

CAS Number

952474-39-4

Target

PARP

Related Pathways

DNA Damage/DNA Repair, Chromatin/Epigenetic

Bioactivity

PARP1-IN-37 (Compound 8) is an orally active and selective inhibitor of poly (ADP-ribose) polymerases 1 and 2 (PARP1/2), with an IC50 value of 24 nM for PARP1. It inhibits PARP activity in cells with an EC50 value of 3.7 μM and holds potential for research on BRCA-mutated tumors, such as breast and ovarian cancers.

Smiles

O=C(N)C1=CC=CC2=CN(N=C21)C=3C=CC=CC3

Molecular Formula

C14H11N3O

Molecular Weight

237.257

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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