TGF?RI-IN-7
Product Specifications
Target
TGF-beta/Smad
Related Pathways
Stem Cells
Bioactivity
TGF?RI-IN-7 (compound 16W) is a potent inhibitor of TGF?RI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGF?RI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.
Smiles
CN(C)CCN1C=C(C=N1)C2=CC3=NC=CC(=C3C=C2)OC4=CN(N=C4C5CCOCC5)C6CC6
Molecular Formula
C27H32N6O2
Molecular Weight
472.582
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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