Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB-Exatecan

Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB-Exatecan (LP1) is a drug-linker conjugate used for ADCs (antibody-drug conjugates) . It comprises a potent DNA topoisomerase I inhibitor, Exatecan, and the linker Mal ((3S,3aR,6S,6aR) -Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12) -β-Glu-PAB, for the synthesis of the ADC AZD0516.

N(C(OCC1=CC(CNC(CCNC([C@@H](NC(CCN2C(=O)C=CC2=O)=O)CCCC(N[C@@H]3[C@@]4([C@](OC3)([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)CO4)[H])[H])=O)=O)=O)=C(O[C@@H]5O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]5O)C=C1)=O)[C@@H]6C7=C8C(C=9N(C8)C(=O)C%10=C(C9)[C@](CC)(O)C(=O)OC%10)=NC=%11C7=C(CC6)C(C)=C(F)C%11