CDK2/FLT4/PDGFRA-IN-1
Product Specifications
Target
CDK|||PDGFR|||Apoptosis|||VEGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint|||Angiogenesis|||Apoptosis
Bioactivity
CDK2/FLT4/PDGFRA-IN-1 (Compound 4a) is a potent inhibitor of CDK2/cyclin A, FLT4 (VEGFR3), and PDGFRA, with IC50 values of 1.672, 0.554, and 0.629 ?M respectively. This compound demonstrates significant antiproliferative effects on cancer cells, including lung cancer EBC-1, pancreatic ductal adenocarcinoma AsPC-1, and colorectal cancer HT-29 cells. Additionally, CDK2/FLT4/PDGFRA-IN-1 can induce apoptosis in these cancer cells.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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