SARM1-IN-4
Product Specifications
CAS Number
3069378-18-0
Target
TLR
Related Pathways
Immunology/Inflammation
Bioactivity
SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.
Smiles
N(C(N([C@@H](C)C=1C=CN=CC1)C)=O)[C@H]2C(F)(F)COC2
Molecular Formula
C13H17F2N3O2
Molecular Weight
285.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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