P2Y14R antagonist 4
Product Specifications
CAS Number
3081687-67-1
Target
P2Y Receptor|||Interleukin
Related Pathways
Immunology/Inflammation|||Neuroscience|||GPCR/G Protein
Bioactivity
Compound 25l, also known as P2Y14R antagonist 4, is an orally active antagonist of the P2Y14R receptor with an IC50 of 5.6 nM. It exhibits higher binding affinity for P2Y14R compared to other PPTN receptors. P2Y14R antagonist 4 also possesses anti-inflammatory properties, reducing the release of pro-inflammatory cytokines (IL-1?, IL-6, and TNF-?) induced by LPS.
Smiles
O=C(O)C1=CC(=CC(=C1)C2=CC=C(C=C2)C3CCNCC3)NS(=O)(=O)CCC4=CC=C(C=C4)C(F)(F)F
Molecular Formula
C27H27F3N2O4S
Molecular Weight
532.574
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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