Mal-N (Me) -C6-N (Me) -PNU-159682
Product Specifications
CAS Number
2682939-57-5
Target
Apoptosis, Drug-Linker Conjugates for ADC
Related Pathways
Apoptosis, Antibody-drug Conjugate/ADC Related
Bioactivity
Mal-N (Me) -C6-N (Me) -PNU-159682 (Compound 27) is an active molecular conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Mal-N (Me) -C6-N (Me) and the potent cytotoxin PNU-159682. This compound selectively delivers its payload to cells expressing CD46 and releases PNU-159682 through cathepsin B cleavage of the linker, inducing DNA damage and apoptosis. Mal-N (Me) -C6-N (Me) -PNU-159682 has demonstrated sustained tumor regression in patient-derived xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) .
Smiles
O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(N(CCCCCCN(C(CN5C(=O)C=CC5=O)=O)C)C)=O)=O)(O)C1)[C@H]6C[C@@]7(N8[C@](O[C@@]7([C@H](C)O6)[H])([C@@H](OC)OCC8)[H])[H]
Molecular Formula
C47H56N4O17
Molecular Weight
948.964
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400270-500 1x 500 µL
Fibronectin (HFN7.1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400218-100 1x 100 µL
CD100 (Semaphorin-4D) (A8), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742848-100 1x 100 µL
Fibronectin (Fn-3), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882312-500 1x 500 µL
SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680053-100 1x 100 µL
HCG-alpha (HCGa/53), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details