2-Guanidinobezimidazole
Product Specifications
CAS Number
5418-95-1
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 ?M for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB) .
Smiles
N=C(N)NC1=NC=2C=CC=CC2N1
Molecular Formula
C8H9N5
Molecular Weight
175.191
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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