EGFR-IN-161
Product Specifications
CAS Number
3031099-34-7
Target
Apoptosis, EGFR
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.
Smiles
C(CCO)N1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCN(C)C)C)C(/N=C/C=5C(Cl)=C(Cl)N=CC5)=C4)=NC=C3
Molecular Formula
C33H36Cl2N8O2
Molecular Weight
647.597
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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