ID11916
Product Specifications
CAS Number
2785317-21-5
Target
Androgen Receptor, PDE
Related Pathways
Metabolism, Endocrinology/Hormones
Bioactivity
ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.
Smiles
N#CC1=NC=C(C=C1C(F)(F)F)N2C(=O)C(N(C=3C=CC(OCC)=C(C3)C4=NC(=O)C5=C(N=C(N5N4)CCC)C)C2=S)(C)C
Molecular Formula
C29H27F3N8O3S
Molecular Weight
624.637
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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