NLRP3-IN-78
Product Specifications
CAS Number
477546-27-3
Target
Pyroptosis|||NF-?B
Related Pathways
Apoptosis|||Immunology/Inflammation|||NF-?B
Bioactivity
NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 ?M. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-?B signaling, demonstrating anti-inflammatory activity.
Smiles
O=C(NC1=NC(=CS1)C=2C=C(Cl)SC2Cl)C=3OC(=CC3)N(=O)=O
Molecular Formula
C12H5Cl2N3O4S2
Molecular Weight
390.222
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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