PAD4-IN-5

Product Specifications

CAS Number

3071873-52-1

Target

PAD

Related Pathways

Chromatin/Epigenetic

Bioactivity

PAD4-IN-5 (Example 18) is a PAD4 inhibitor with an IC50 of ≤10 nM at 50 μM Ca2+ and 101-500 nM at 1 mM Ca2+ against human PAD4 (hPAD4) . This compound is applicable in the study of autoimmune diseases such as rheumatoid arthritis (RA) .

Smiles

CN1C(C=2N3C=4C(C2)=CC=C(N4)[C@@H](C)NC(=O)[C@]5([C@](CCCCC3)(C5)[H])[H])=NC=6C1=CC7=C(C6)C(=O)N(C[C@H]8COCCN8)CC7

Molecular Formula

C34H41N7O3

Molecular Weight

595.734

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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