CHD-1
Product Specifications
CAS Number
3041166-70-2
Target
Apoptosis, Mitophagy
Related Pathways
Autophagy, Apoptosis
Bioactivity
CHD-1 is a hypoxia-activated antitumor prodrug. It disrupts the mitochondrial morphology and membrane potential of hypoxic tumor cells, leading to excessive mitophagy and inducing apoptosis. In vitro, CHD-1 inhibits the growth of hypoxic tumor cells, while in vivo, it suppresses the growth of HeLa xenograft tumors.
Smiles
C(/C=C/C1=CC(N(=O)=O)=CC=C1)(=O)C2=CC(F)=C(OC)C=C2
Molecular Formula
C16H12FNO4
Molecular Weight
301.269
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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