What is the catalog number for HCES2A-IN-2?

The catalog number for HCES2A-IN-2 is T206726.

What sizes are available for HCES2A-IN-2?

HCES2A-IN-2 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does HCES2A-IN-2 come in?

HCES2A-IN-2 is available in 2 different pack sizes.

Is HCES2A-IN-2 in stock?

HCES2A-IN-2 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HCES2A-IN-2?

HCES2A-IN-2 is manufactured by Molfinity.

What is the estimated delivery time for HCES2A-IN-2?

Estimated delivery time for HCES2A-IN-2 is approximately 10 business day(s), depending on your location.

HCES2A-IN-2

Product Specifications

Target

Lipid

Related Pathways

Metabolism

Bioactivity

HCES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible, covalent inhibitor of hCES2A with an IC50 of 0.04 nM. It targets and covalently binds to the catalytic serine residue (Ser-228) of hCES2A. hCES2A-IN-2 can significantly mitigate irinotecan-induced gastrointestinal toxicity (ITGT) without diminishing the antitumor efficacy of irinotecan in tumor-bearing mice.