VVD-699
Product Specifications
CAS Number
3055319-82-6
Target
PI3K, Ras
Related Pathways
PI3K/Akt/mTOR signaling, MAPK, GPCR/G Protein
Bioactivity
VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.
Smiles
S(=O)(=O)(C1=C(C=C(OC)C=C1)C2=C(Cl)C=CC=C2)N3[C@H](C)C[C@@](C(N[C@@H](/C=C\S(C)(=O)=O)C)=O)(F)CC3
Molecular Formula
C25H30ClFN2O6S2
Molecular Weight
573.097
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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