NLRP3-IN-76

Product Specifications

Target

Interleukin|||NF-?B|||NOD-like Receptor (NLR) |||NO Synthase

Related Pathways

Immunology/Inflammation|||NF-?B

Bioactivity

NLRP3-IN-76 is an orally active NLRP3 inhibitor that suppresses the production of NO and reduces the mRNA levels of pro-inflammatory cytokines (iNOS, IL-6, IL-1?, and TNF?) . It exerts anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome and the NF-?B signaling pathway. Furthermore, NLRP3-IN-76 can ameliorate DSS-induced colitis and is applicable for studying inflammatory bowel disease (IBD) .