R1-ICR-5
Product Specifications
CAS Number
3070346-91-4
Target
TLR, PROTACs, NF-κB, p38 MAPK, Serine/threonin kinase, TNF
Related Pathways
Apoptosis, Immunology/Inflammation, PROTAC, MAPK, Cell Cycle/Checkpoint, NF-κB, Metabolism
Bioactivity
R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1) . Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.
Smiles
N(C(CCCCCCCCCCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)[C@](C)(C)C)=O)=O)C=4SC=5C(N4)=CC=C(C5)C=6C=C(NC(OC7CCCCC7)=O)C(C)=NC6
Molecular Formula
C54H70N8O7S2
Molecular Weight
1007.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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