R1-ICR-5

Product Specifications

CAS Number

3070346-91-4

Target

TLR|||PROTACs|||NF-?B|||p38 MAPK|||Serine/threonin kinase|||TNF

Related Pathways

Apoptosis|||Immunology/Inflammation|||PROTAC|||MAPK|||Cell Cycle/Checkpoint|||NF-?B|||Metabolism

Bioactivity

R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1) . Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-?B, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.

Smiles

N(C(CCCCCCCCCCC(N[C@H](C(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)[C@](C)(C)C)=O)=O)C=4SC=5C(N4)=CC=C(C5)C=6C=C(NC(OC7CCCCC7)=O)C(C)=NC6