CDD-2789
Product Specifications
CAS Number
3052084-77-9
Target
TGF-beta/Smad|||ALK
Related Pathways
Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors
Bioactivity
CDD-2789 is a highly selective small molecule inhibitor that targets Activin receptor type 1 (ALK2, also known as ACVR1) . It effectively blocks the BMP and activin A-induced downstream phosphorylation reactions by inhibiting the ALK2/ALK1-mediated SMAD1/5 signaling pathway. In the NanoBRET cell model, CDD-2789 demonstrates an inhibitory activity with an IC50 value of 0.54 µM for ALK2. This compound holds potential for research in ALK2-related diseases, including brainstem glioma (DIPG), ependymoma, endometrial cancer, melanoma, non-small cell lung cancer, colorectal cancer, and pancreatic cancer.
Smiles
O=C(NCCCN(C)C)C1=CC=C2N=C(C=3C=C(OC)C(OC)=C(OC)C3)N(C2=C1)C4CCC4
Molecular Formula
C26H34N4O4
Molecular Weight
466.573
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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