PLK1-IN-13
Product Specifications
CAS Number
3038489-48-1
Target
Apoptosis, c-Myc, PLK
Related Pathways
Cell Cycle/Checkpoint, Apoptosis
Bioactivity
PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM) . PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML) .
Smiles
C(C)[C@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C(C=C3)C=4SC(CN5CCN(C)CC5)=NN4)N2)C6CCCC6
Molecular Formula
C29H39N9O2S
Molecular Weight
577.744
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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