TAK-075
Product Specifications
CAS Number
667931-33-1
Target
CaSR
Related Pathways
GPCR/G Protein
Bioactivity
TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.
Smiles
S(=O)(=O)(O)C1=CC=C(C)C=C1.C(NC(CC)(CC)C1=CC=C(CC)C=C1)(=O)C2=C3N(C(C)(C)C[C@@H](N3)C4=CC=CC=C4)N=C2C
Molecular Formula
C36H46N4O4S
Molecular Weight
630.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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