PDE2 inhibitor 6
Product Specifications
CAS Number
2097493-39-3
Target
PDE|||iGluR
Related Pathways
Metabolism|||Membrane transporter/Ion channel|||Neuroscience
Bioactivity
PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 ?M (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.
Smiles
C[C@H]1[C@H](C=2N3C(N=C(C(F)F)C2)=NC=N3)CN(C(=O)C=4C=C(C)N=C(C)C4)CC1
Molecular Formula
C20H22F2N6O
Molecular Weight
400.425
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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