Microtubulin-IN-1
Product Specifications
CAS Number
3025180-14-4
Target
Apoptosis, MDM-2/p53, Microtubule Associated
Related Pathways
Cytoskeletal Signaling, Apoptosis
Bioactivity
Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.
Smiles
C(\C=1N(C(C)C)C=CN1)=C\2/C(=O)N/C(=C\C3=CC(C(=O)C4=CC=C(F)C=C4)=CC=C3)/C(=O)N2
Molecular Formula
C25H21FN4O3
Molecular Weight
444.458
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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